Target：SRp20

Fields：Spliceosome;Amyotrophic lateral sclerosis;Herpes simplex virus 1 infection

Gene Name：SRSF3

Protein Name：Serine/arginine-rich splicing factor 3

Human Gene Id：6428

Human Swiss Prot No：P84103

Mouse Gene Id：20383

Mouse Swiss Prot No：P84104

Immunogen：The antiserum was produced against synthesized peptide derived from human SFRS3. AA range:111-160

Specificity：SRp20 Polyclonal Antibody detects endogenous levels of SRp20 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：SRSF3;SFRS3;SRP20;Serine/arginine-rich splicing factor 3;Pre-mRNA-splicing factor SRP20;Splicing factor; arginine/serine-rich 3

Observed Band(KD)：25kD

Background： The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene. [provided by RefSeq, Sep 2010],

Function：function:May be involved in RNA processing in relation with cellular proliferation and/or maturation.,PTM:Extensively phosphorylated on serine residues in the RS domain.,similarity:Belongs to the splicing factor SR family.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Interacts with CPSF6, RBMY1A1 and SFRS12.,

Subcellular Location：Nucleus . Nucleus speckle . Cytoplasm . Recruited to nuclear speckles following interaction with YTHDC1. .

Expression： Brain,Epithelium,Placenta,Tongue,