Target：SR-7

Fields：Ras signaling pathway;Calcium signaling pathway;Neuroactive ligand-receptor interaction;Serotonergic synapse

Gene Name：HTR7

Protein Name：5-hydroxytryptamine receptor 7

Human Gene Id：3363

Human Swiss Prot No：P34969

Mouse Gene Id：15566

Mouse Swiss Prot No：P32304

Rat Gene Id：65032

Rat Swiss Prot No：P32305

Immunogen：The antiserum was produced against synthesized peptide derived from human HTR7. AA range:391-440

Specificity：SR-7 Polyclonal Antibody detects endogenous levels of SR-7 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：HTR7;5-hydroxytryptamine receptor 7;5-HT-7;5-HT7;5-HT-X;Serotonin receptor 7

Molecular Weight(Da)：54kD

Background： The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008],

Function：alternative products:Isoform A and isoform B appear to be expressed at higher levels,function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels, and isoform D is a minor isoform.,

Subcellular Location：Cell membrane; Multi-pass membrane protein.

Expression：Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels. Isoform D is a minor isoform in terms of expression.