Target：SR-6
Fields：Calcium signaling pathway;cAMP signaling pathway;Neuroactive ligand-receptor interaction;Serotonergic synapse
Gene Name：HTR6
Protein Name：5-hydroxytryptamine receptor 6
Human Gene Id：3362
Human Swiss Prot No：P50406
Mouse Gene Id：15565
Mouse Swiss Prot No：Q9R1C8
Rat Gene Id：64354
Rat Swiss Prot No：P31388
Immunogen：The antiserum was produced against synthesized peptide derived from human 5-HT-6. AA range:221-270
Specificity：SR-6 Polyclonal Antibody detects endogenous levels of SR-6 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：HTR6;5-hydroxytryptamine receptor 6;5-HT-6;5-HT6;Serotonin receptor 6
Observed Band(KD)：47kD
Background： This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013],
Function：function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in several human brain regions, most prominently in the caudate nucleus.,
Subcellular Location：Cell membrane; Multi-pass membrane protein.
Expression：Expressed in several human brain regions, most prominently in the caudate nucleus.
