Target：HSP105

Fields：Protein processing in endoplasmic reticulum

Gene Name：HSPH1

Protein Name：Heat shock protein 105 kDa

Human Gene Id：10808

Human Swiss Prot No：Q92598

Mouse Gene Id：15505

Mouse Swiss Prot No：Q61699

Immunogen：The antiserum was produced against synthesized peptide derived from human HSP105. AA range:791-840

Specificity：HSP105 Polyclonal Antibody detects endogenous levels of HSP105 protein.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：HSPH1;HSP105;HSP110;KIAA0201;Heat shock protein 105 kDa;Antigen NY-CO-25;Heat shock 110 kDa protein

Observed Band(KD)：100kD

Background：function:Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities.,PTM:Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity.,similarity:Belongs to the heat shock protein 70 family.,subunit:Interacts with HSPA8/HSC70.,tissue specificity:Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.,

Function：function:Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities.,PTM:Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity.,similarity:Belongs to the heat shock protein 70 family.,subunit:Interacts with HSPA8/HSC70.,tissue specificity:Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.,

Subcellular Location：Cytoplasm .

Expression：Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.