METTL14 Rabbit Polyclonal Antibody (QYA10774)

产品名称：METTL14兔多克隆抗体

货号：QYA10774

 

主要参数

应用：WB

适应物种：Human, Mouse, Rat

分子量：60KD

同种型：IgG

储存温度：-20℃

建议工作浓度：WB:1:2000-5000

特异性：抗体可以检测内源性METTL14蛋白

其他名称：KIAA1627, Methyltransferase like 14

 

背景

METTL3-METTL14异二聚体可形成N6甲基转移酶复合物，该复合物能够介导部分mRNA腺苷残基的N6位点甲基化，并参与调控生物钟节律、胚胎干细胞分化及皮质层神经发生过程。

在与METTL3形成的异二聚体中，METTL14主要发挥RNA结合支架功能，负责特异性识别底物而非构成催化核心。

 

 

注：本产品仅用于科研用途，不用于诊断和治疗。

Product name: METTL14 Rabbit Polyclonal Antibody

Cat: QYA10774

 

Main parameter

Applications: WB

Reactivity: Human, Mouse, Rat

Protein MW: 60KD

Isotype: IgG

Storage: -20℃

Recommended dilutions: WB:1:2000-5000

Specificity: Antibody can detects endogenous METTL14 protein.

Alternative Names: KIAA1627, Methyltransferase like 14

 

Background

The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N6 position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis.

In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. 

 

 

P.s. This product is only used for scientific research, not for diagnosis and treatment.