Main Information

Target

CD19

Host Species

Mouse

Reactivity

Human

Applications

Flow Cyt, ELISA

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

ELISA 1:5000-100000; Flow Cyt 1-2μg/Test

Formulation

Phosphate-buffered solution

Specificity

This recombinant monoclonal antibody can detects endogenous levels of CD19 protein.

Purification

Recombinant Expression and Affinity purified

Storage

-15°C to -25°C/1 year(Avoid freeze / thaw cycles)

Concentration

Please check the information on the tube

Modification

Unmodified

Clonality

Monoclonal

Clone Number

PTR1382

Isotype

IgG1,Kappa

Antigen&Target Information

Immunogen:

Purified recombinant Human CD19

Specificity:

This recombinant monoclonal antibody can detects endogenous levels of CD19 protein.

Gene Name:

CD19

Protein Name:

B-lymphocyte antigen CD19 (B-lymphocyte surface antigen B4) (Differentiation antigen CD19) (T-cell surface antigen Leu-12) (CD antigen CD19)

Other Name:

B-lymphocyte antigen CD19 ;
Cd19 ;
Differentiation antigen CD19 ;
CD19 ;
Antibody deficiency due to defect in CD19 antibody ;
Antibody deficiency due to defect in CD19 ;
included antibody ;
AW495831 antibody ;
B lymphocyte antigen CD19 antibody ;
B lymphocyte surface antigen B4 antibody ;
B-lymphocyte antigen CD19 antibody ;
B-lymphocyte surface antigen B4 antibody ;
B4 antibody ;
CD19 antibody ;
CD19 antigen antibody ;
CD19 molecule antibody ;
Cd19 protein antibody ;
CD19_HUMAN antibody ;
CVID3 antibody ;
Differentiation antigen CD19 antibody ;
Leu 12 antibody ;
Leu-12 antibody ;
Leu12 antibody ;
MGC109570 antibody ;
MGC12802 antibody ;
T-cell surface antigen Leu-12 antibody ;

Database Link:

Organism	Gene ID	SwissProt
Human	930;	P15391;

Background:

CD19 molecule(CD19) Homo sapiens Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors.This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]

Function:

Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens . Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores . Is not required for early steps during B cell differentiation in the blood marrow . Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges . Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge .

Cellular Localization:

Cell membrane ; Single-pass type I membrane protein . Membrane raft ; Single-pass type I membrane protein .

Tissue Expression:

Detected on marginal zone and germinal center B cells in lymph nodes (PubMed:24631). Detected on blood B cells (at protein level) (PubMed:24631, PubMed:1667271).