Main Information

Target

CHM4B

Host Species

Rabbit

Reactivity

Human, Mouse

Applications

WB

MW

25kD (Calculated)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

WB 1:1000-2000

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

This antibody detects endogenous levels of human CHM4B

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Calculated)

25kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthesized peptide derived from human CHM4B AA range: 50-100

Specificity:

This antibody detects endogenous levels of human CHM4B

Gene Name:

CHMP4B C20orf178 SHAX1

Protein Name:

Charged multivesicular body protein 4b (Chromatin-modifying protein 4b) (CHMP4b) (SNF7 homolog associated with Alix 1) (SNF7-2) (hSnf7-2) (Vacuolar protein sorting-associated protein 32-2) (Vps32-2) (hVps32-2)

Database Link:

Organism	Gene ID	SwissProt
Human	128866;	Q9H444;
Mouse	75608;	Q9D8B3;

Cellular Localization:

Cytoplasm, cytosol . Late endosome membrane ; Peripheral membrane protein . Midbody . Nucleus envelope . Recruited to the nuclear envelope by CHMP7 during late anaphase (PubMed:26040712). Localizes transiently to the midbody arms immediately before abscission (PubMed:22422861). .

Tissue Expression:

Widely expressed. Expressed at higher level in heart and skeletal muscle. Also expressed in brain, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood lymphocytes.

Research Areas:

>>Viral life cycle - HIV-1 ;
>>Endocytosis ;
>>Necroptosis