Main Information

Target

CD19

Host Species

Rabbit

Reactivity

Human,

Applications

WB, IHC, IF, IP, ELISA

MW

110kD (Calculated)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

IHC 1:200-1000; WB 1:1000-5000; IF 1:200-1000; ELISA 1:5000-20000; IP 1:50-200

Formulation

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Specificity

Endogenous

Purification

Protein A

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

MW(Calculated)

110kD

MW(Observed)

110kD

Modification

Unmodified

Clonality

Monoclonal

Clone Number

PT0089R

Isotype

IgG,Kappa

Antigen&Target Information

Specificity:

Endogenous

Gene Name:

CD19

Protein Name:

B-lymphocyte antigen CD19 (B-lymphocyte surface antigen B4) (Differentiation antigen CD19) (T-cell surface antigen Leu-12) (CD antigen CD19)

Database Link:

Organism	Gene ID	SwissProt
Human	930;	P15391;
Mouse	12478;	P25918;

Background:

CD19 molecule(CD19) Homo sapiens Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008],

Function:

Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens . Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores . Is not required for early steps during B cell differentiation in the blood marrow . Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges . Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge .

Cellular Localization:

Membranous

Tissue Expression:

Detected on marginal zone and germinal center B cells in lymph nodes (PubMed:2463100). Detected on blood B cells (at protein level) (PubMed:2463100, PubMed:16672701).