Main Information

Target

LDHD

Host Species

Rabbit

Reactivity

Human, Mouse, Rat

Applications

WB

MW

55kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

WB 1:1000-5000

Formulation

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Specificity

The antibody detects endogenous LDHD protein.

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

MW(Observed)

55kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Recombinant Protein of LDHD

Specificity:

The antibody detects endogenous LDHD protein.

Gene Name:

LDHD

Protein Name:

Probable D-lactate dehydrogenase, mitochondrial

Other Name:

Probable D-lactate dehydrogenase, mitochondrial ;
DLD ;
Lactate dehydrogenase D ;

Database Link:

Organism	Gene ID	SwissProt
Human	197257;	Q86WU2;
Mouse	52815;	Q7TNG8;

Background:

The protein encoded by this gene belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. The similar protein in yeast has both D-lactate and D-glycerate dehydrogenase activities. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008],

Function:

Catalytic activity:(R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.,cofactor:FAD.,similarity:Belongs to the FAD-binding oxidoreductase/transferase type 4 family.,similarity:Contains 1 FAD-binding PCMH-type domain.,subunit:Interacts with CSRP3.,tissue specificity:Expressed moderately in heart and liver and at lower levels in skeletal muscle and kidney.,

Cellular Localization:

Mitochondrion .

Tissue Expression:

Expressed moderately in heart and liver and at lower levels in skeletal muscle and kidney.

Research Areas:

>>Pyruvate metabolism ;
>>Metabolic pathways