Main Information

Target

Tubulin β

Host Species

Mouse

Reactivity

Human, Mouse, Rat, Bovine, Rabbit

Applications

WB, IP

MW

50kD (Calculated)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

WB 1:1000-1:2000; Not yet tested in other applications.

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

Tubulin β Monoclonal Antibody detects endogenous levels of Tubulin β protein.

Purification

Affinity purification

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

MW(Calculated)

50kD

Modification

Unmodified

Clonality

Monoclonal

Antigen&Target Information

Immunogen:

Purified recombinant human Tubulin β protein fragments expressed in E.coli.

Specificity:

Tubulin β Monoclonal Antibody detects endogenous levels of Tubulin β protein.

Gene Name:

TUBB1

Protein Name:

Tubulin beta-1 chain

Other Name:

TUBB1 ;
Tubulin beta-1 chain

Database Link:

Organism	Gene ID	SwissProt
Human	81027;	P07437;
Mouse	545486;	A2AQ07;

Background:

This gene encodes a member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is specifically expressed in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. A mutations in this gene is associated with autosomal dominant macrothrombocytopenia. Two pseudogenes of this gene are found on chromosome Y.[provided by RefSeq, Jul 2010],

Function:

Function:Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.,similarity:Belongs to the tubulin family.,subunit:Dimer of alpha and beta chains.,

Cellular Localization:

Cytoplasm, cytoskeleton .

Tissue Expression:

Hematopoietic cell-specific. Major isotype in leukocytes, where it represents 50% of all beta-tubulins.

Research Areas:

>>Phagosome ;
>>Gap junction ;
>>Alzheimer disease ;
>>Parkinson disease ;
>>Amyotrophic lateral sclerosis ;
>>Huntington disease ;
>>Prion disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Pathogenic Escherichia coli infection ;
>>Salmonella infection