Main Information

Target

Ribosomal Protein S27

Host Species

Mouse

Reactivity

Human

Applications

IF, ELISA

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications;

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

Ribosomal Protein S27 Monoclonal Antibody detects endogenous levels of Ribosomal Protein S27 protein.

Purification

Affinity purification

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Modification

Unmodified

Clonality

Monoclonal

Antigen&Target Information

Immunogen:

Purified recombinant fragment of Ribosomal Protein S27 expressed in E. Coli.

Specificity:

Ribosomal Protein S27 Monoclonal Antibody detects endogenous levels of Ribosomal Protein S27 protein.

Gene Name:

RPS27

Protein Name:

40S ribosomal protein S27

Other Name:

RPS27 ;
MPS1 ;
40S ribosomal protein S27 ;
Metallopan-stimulin 1 ;
MPS-1

Database Link:

Organism	Gene ID	SwissProt
Human	6232;	P42677;
Mouse		Q6ZWU9;

Background:

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S27E family of ribosomal proteins. It contains a C4-type zinc finger domain that can bind to zinc. The encoded protein has been shown to be able to bind to nucleic acid. It is located in the cytoplasm as a ribosomal component, but it has also been detected in the nucleus. Studies in rat indicate that ribosomal protein S27 is located near ribosomal protein S18 in the 40S subunit and is covalently linked to translation initiation factor eIF3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [pr

Function:

Caution:Was originally (PubMed:8407955) thought to be a protein that could have played a role as a potentially important mediator of cellular proliferative responses to various growth factors and other environmental signals. Capable of specific binding to a cAMP response element in DNA.,cofactor:Binds 1 zinc ion per subunit .,cofactor:Binds 1 zinc ion per subunit.,similarity:Belongs to the ribosomal protein S27e family.,tissue specificity:Expressed in a wide variety of actively proliferating cells and tumor tissues.,

Cellular Localization:

nucleus,nucleoplasm,cytosol,ribosome,cytosolic small ribosomal subunit,

Tissue Expression:

Expressed in a wide variety of actively proliferating cells and tumor tissues.

Research Areas:

>>Ribosome ;
>>Coronavirus disease - COVID-19