Main Information

Target

ST2A1

Host Species

Rabbit

Reactivity

Human, Rat, Mouse,

Applications

WB, IHC, IF, ELISA

MW

34kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

This antibody detects endogenous levels of human ST2A1

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Observed)

34kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthesized peptide derived from human ST2A1

Specificity:

This antibody detects endogenous levels of human ST2A1

Gene Name:

SULT2A1 HST STD

Protein Name:

ST2A1

Other Name:

Bile salt sulfotransferase ;
Dehydroepiandrosterone sulfotransferase ;
DHEA-ST ;
Hydroxysteroid Sulfotransferase ;
HST ;
ST2 ;
ST2A3 ;
Sulfotransferase 2A1 ;
ST2A1 ;

Database Link:

Organism	Gene ID	SwissProt
Human	6822;	Q06520;

Background:

This gene encodes a member of the sulfotransferase family. Sulfotransferases aid in the metabolism of drugs and endogenous compounds by converting these substances into more hydrophilic water-soluble sulfate conjugates that can be easily excreted. This protein catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands, and may have a role in the inherited adrenal androgen excess in women with polycystic ovary syndrome. [provided by RefSeq, Mar 2010],

Function:

Catalytic activity:3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate.,Catalytic activity:3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate.,Function:Catalyzes the sulfation of steroids and bile acids in the liver and adrenal glands.,miscellaneous:Estrogens present in maternal circulation is predominantly derived from fetal dehydroepiandosterone sulfate which is hydrolyzed and metabolized to estrogens in placenta.,PTM:The N-terminus is blocked.,similarity:Belongs to the sulfotransferase 1 family.,subunit:Homodimer.,tissue specificity:Liver, adrenal and at lower level in the kidney. Is present in human fetus in higher level in the adrenal than the liver and the kidney.,

Cellular Localization:

Cytoplasm .

Tissue Expression:

Liver, adrenal and at lower level in the kidney. Is present in human fetus in higher level in the adrenal than the liver and the kidney.

Research Areas:

>>Metabolism of xenobiotics by cytochrome P450 ;
>>Bile secretion ;
>>Chemical carcinogenesis - DNA adducts