Main Information

Target

CALHM1

Host Species

Rabbit

Reactivity

Human, Rat

Applications

WB, IHC, IF

MW

40kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

WB 1:500-1000; IHC 1:200-500; IF 1:50-200

Formulation

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Specificity

The antibody detects endogenous CALHM1 protein.

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

MW(Observed)

40kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthetic Peptide of CALHM1 AA range: 204-254

Specificity:

The antibody detects endogenous CALHM1 protein.

Gene Name:

CALHM1

Protein Name:

Calcium homeostasis modulator protein 1

Other Name:

Calcium homeostasis modulator protein 1 ;
Protein FAM26C

Database Link:

Organism	Gene ID	SwissProt
Human	255022;	Q8IU99;

Background:

calcium homeostasis modulator 1(CALHM1) Homo sapiens This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.[provided by RefSeq, Mar 2010],

Function:

Function:May be a pore-forming ion channel. Controls cytosolic Ca(2+) permeability and cytosolic Ca(2+) concentration. Controls amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner.,polymorphism:Leu-86 causes a dysregulation of Ca(2+) homeostasis and amyloid precursor protein (APP) metabolism, and may be a risk factor for the development of Alzheimer's disease.,similarity:Belongs to the FAM26 family.,subcellular location:Colocalizes with HSPA5 at the endoplasmic reticulum.,subunit:Homooligomer; homomultimerized to form dimeric and possibly tetrameric structures.,tissue specificity:Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells.,

Cellular Localization:

Cell membrane; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein . Colocalizes with HSPA5 at the endoplasmic reticulum (PubMed:18585350). Localizes to the basolateral membrane of epithelial cells including taste cells (By similarity). .

Tissue Expression:

Predominantly expressed in adult brain. Detected also in retinoic acid-differentiated SH-SY5Y cells. Specifically expressed in circumvallate taste bud cells.

Research Areas:

>>Taste transduction