Main Information

Target

Gab 1

Host Species

Rabbit

Reactivity

Human, Mouse, Rat

Applications

IHC, IF

MW

76kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

IHC 1:50-300; IF 1:50-200

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

The antibody detects endogenous Gab1 protein

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Observed)

76kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Recombinant Protein of Gab1

Specificity:

The antibody detects endogenous Gab1 protein

Gene Name:

GAB1

Protein Name:

GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)

Other Name:

GRB2-associated-binding protein 1 ;
GRB2-associated binder 1 ;
Growth factor receptor bound protein 2-associated protein 1 ;

Database Link:

Organism	Gene ID	SwissProt
Human	2549;	Q13480;
Mouse		Q9QYY0;

Background:

GRB2 associated binding protein 1(GAB1) Homo sapiens The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],

Function:

Function:Probably involved in EGF and insulin receptor signaling.,PTM:Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains.,similarity:Belongs to the GAB family.,similarity:Contains 1 PH domain.,subunit:Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2.,

Cellular Localization:

cytosol,

Tissue Expression:

Testis,Whole embryo,

Research Areas:

>>EGFR tyrosine kinase inhibitor resistance ;
>>ErbB signaling pathway ;
>>Ras signaling pathway ;
>>Phospholipase D signaling pathway ;
>>Neurotrophin signaling pathway ;
>>Bacterial invasion of epithelial cells ;
>>Proteoglycans in cancer ;
>>Renal cell carcinoma ;
>>Hepatocellular carcinoma ;
>>Gastric cancer