Main Information

Target

KCNK10

Host Species

Rabbit

Reactivity

Human, Rat

Applications

WB, IHC, IF

MW

59kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

WB 1:1000-2000; IHC 1:100-200; IF 1:50-200

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Specificity

KCNK10(TREK-2) protein(A237) detects endogenous levels of KCNK10(TREK-2)

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

Concentration

1 mg/ml

MW(Observed)

59kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthetic Peptide of KCNK10 (TREK-2) AA range: 16-66

Specificity:

KCNK10(TREK-2) protein(A237) detects endogenous levels of KCNK10(TREK-2)

Gene Name:

KCNK10

Protein Name:

Potassium channel subfamily K member 10 (Outward rectifying potassium channel protein TREK-2) (TREK-2 K(+) channel subunit)

Other Name:

Potassium channel subfamily K member 10 ;
Outward rectifying potassium channel protein TREK-2 ;
TREK-2 K ;
+ ;
channel subunit ;

Database Link:

Organism	Gene ID	SwissProt
Human	54207;	P57789;
Rat		Q9JIS4;

Background:

potassium two pore domain channel subfamily K member 10(KCNK10) Homo sapiens The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008],

Function:

Function:Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.,similarity:Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.,tissue specificity:Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain.,

Cellular Localization:

Membrane ; Multi-pass membrane protein .

Tissue Expression:

Abundantly expressed in pancreas and kidney and to a lower level in brain, testis, colon, and small intestine. Isoform b is strongly expressed in kidney (primarily in the proximal tubule) and pancreas, whereas isoform c is abundantly expressed in brain.

Research Areas:

>>Gastric acid secretion