Main InformationTargetTubulin β IIHost SpeciesRabbitReactivityHuman, Mouse, RatApplicationsWB, IFMW50kD (Observed)Conjugate/ModificationUnmodifiedDetailed InformationRecommended Dilution RatioWB 1:500-2000; IF/ICC1:100-500FormulationPBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.SpecificityThe antibody detects endogenous β II tubulin protein.PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.Storage-15°C to -25°C/1 year(Do not lower than -25°C)MW(Observed)50kDModificationUnmodifiedClonalityPolyclonalIsotypeIgGAntigen&Target InformationImmunogen:Synthetic Peptide of β II Tubulin AA range: 80-130Specificity:The antibody detects endogenous β II tubulin protein.Gene Name:TUBB2AProtein Name:Tubulin beta-2A chainOther Name:Tubulin beta-2A chainDatabase Link:Background:Microtubules, key participants in processes such as mitosis and intracellular transport, are composed of heterodimers of alpha- and beta-tubulins. The protein encoded by this gene is a beta-tubulin. Defects in this gene are associated with complex cortical dysplasia with other brain malformations-5. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2015],Function:Function:Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.,similarity:Belongs to the tubulin family.,subunit:Dimer of alpha and beta chains.,Cellular Localization:Cytoplasm, cytoskeleton .Tissue Expression:High expression in brain, where it represents 30% of all beta-tubulins.Research Areas:>>Phagosome ; >>Gap junction ; >>Alzheimer disease ; >>Parkinson disease ; >>Amyotrophic lateral sclerosis ; >>Huntington disease ; >>Prion disease ; >>Pathways of neurodegeneration - multiple diseases ; >>Pathogenic Escherichia coli infection ; >>Salmonella infection