Main Information

Target

Tubulin β II

Host Species

Rabbit

Reactivity

Human, Mouse, Rat

Applications

WB, IF

MW

50kD (Observed)

Conjugate/Modification

Unmodified

Detailed Information

Recommended Dilution Ratio

WB 1:500-2000; IF/ICC1:100-500

Formulation

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Specificity

The antibody detects endogenous β II tubulin protein.

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Storage

-15°C to -25°C/1 year(Do not lower than -25°C)

MW(Observed)

50kD

Modification

Unmodified

Clonality

Polyclonal

Isotype

IgG

Antigen&Target Information

Immunogen:

Synthetic Peptide of β II Tubulin AA range: 80-130

Specificity:

The antibody detects endogenous β II tubulin protein.

Gene Name:

TUBB2A

Protein Name:

Tubulin beta-2A chain

Other Name:

Tubulin beta-2A chain

Database Link:

Organism	Gene ID	SwissProt
Human	7280;	Q13885;
Mouse	22151;	Q7TMM9;
Rat	498736;	P85108;

Background:

Microtubules, key participants in processes such as mitosis and intracellular transport, are composed of heterodimers of alpha- and beta-tubulins. The protein encoded by this gene is a beta-tubulin. Defects in this gene are associated with complex cortical dysplasia with other brain malformations-5. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2015],

Function:

Function:Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.,similarity:Belongs to the tubulin family.,subunit:Dimer of alpha and beta chains.,

Cellular Localization:

Cytoplasm, cytoskeleton .

Tissue Expression:

High expression in brain, where it represents 30% of all beta-tubulins.

Research Areas:

>>Phagosome ;
>>Gap junction ;
>>Alzheimer disease ;
>>Parkinson disease ;
>>Amyotrophic lateral sclerosis ;
>>Huntington disease ;
>>Prion disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Pathogenic Escherichia coli infection ;
>>Salmonella infection