Target：TGF β Receptor I

Fields：MAPK signaling pathway;Cytokine-cytokine receptor interaction;FoxO signaling pathway;Endocytosis;Cellular senescence;TGF-beta signaling pathway;Apelin signaling pathway;Osteoclast differentiation;Hippo signaling pathway;Adherens junction;Th17 cell differentiation;Relaxin signaling pathway;AGE-RAGE signaling pathway in diabetic complications;Chagas disease;Hepatitis B;Human T-cell leukemia virus 1 infection;Pathways in cancer;Colorectal cancer;Pancreatic cancer;Chronic myeloid leukemia;Hepatocellular carcinoma;Gastric cancer;Diabetic cardiomyopathy

Gene Name：TGFBR1 ALK5 SKR4

Protein Name：TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4)

Human Gene Id：7046

Human Swiss Prot No：P36897

Immunogen：Synthesized peptide derived from human TGF β Receptor I AA range: 34-100

Specificity：This antibody detects endogenous levels of TGF β Receptor I protein.

Formulation：PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Source：Mouse, Monoclonal/IgG2a, kappa

Dilution：IHC 1:50-200. IF 1:50-200. ELISA 1:500-5000

Purification：The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Molecular Weight(Da)：55kD

Observed Band(KD)：55kD

Background： The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],

Function：catalytic activity:ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.,cofactor:Magnesium or manganese.,disease:Defects in TGFBR1 are the cause of aortic aneurysm familial thoracic type 5 (AAT5) [MIM:608967]. Aneurysms and dissections of the aorta usually result from degenerative changes in the aortic wall. Thoracic aortic aneurysms and dissections are primarily associated with a characteristic histologic appearance known as 'medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.,disease:Defects in TGFBR1 are the cause of Loeys-Dietz syndrome type 1A (LDS1A) [MIM:609192]; also known as Furlong syndrome or Loeys-Dietz aortic aneurysm syndrome (LDAS). LDS1 is an aortic aneurysm syndrome with widespread systemic involvement. The disorder is characterized by arterial tort

Subcellular Location：Membranous

Expression：Found in all tissues examined, most abundant in placenta and least abundant in brain and heart. Expressed in a variety of cancer cell lines (PubMed:25893292).