Target:LALBA
Fields:Galactose metabolism;Metabolic pathways
Gene Name:LALBA
Protein Name:Alpha-lactalbumin
Human Gene Id:3906
Human Swiss Prot No:P00709
Mouse Gene Id:16770
Mouse Swiss Prot No:P29752
Rat Gene Id:24528
Rat Swiss Prot No:P00714
Immunogen:Synthetic Peptide of alpha Lactalbumin
Specificity:The antibody detects endogenous alpha Lactalbumin proteins.
Formulation:PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Source:Monoclonal, Mouse
Dilution:WB 1:1000 IF 1:200 IHC 1:50-300
Purification:The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:Alpha-lactalbumin (Lactose synthase B protein) (Lysozyme-like protein 7)
Observed Band(KD):16kD
Background: This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. [provided by RefSeq, Jul 2008],
Function:function:Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.,similarity:Belongs to the glycosyl hydrolase 22 family.,subunit:Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).,tissue specificity:Mammary gland specific. Secreted in milk.,
Subcellular Location:Secreted.
Expression:Mammary gland specific. Secreted in milk.