Target：GAP-43
Gene Name：GAP43
Protein Name：Neuromodulin
Human Gene Id：2596
Human Swiss Prot No：P17677
Mouse Swiss Prot No：P06837
Rat Swiss Prot No：P07936
Immunogen：Recombinant Protein of GAP-43
Specificity：The antibody detects endogenous GAP-43 protein.
Formulation：PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Source：Monoclonal, Mouse
Dilution：WB 1:1000-2000 IHC 1:200-500. IF 1:50-200
Purification：The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：GAP43;Neuromodulin;Axonal membrane protein GAP-43;Growth-associated protein 43;Neural phosphoprotein B-50;pp46
Observed Band(KD)：38,43kD
Background： The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function：function:This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons.,online information:Gap-43 entry,PTM:Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.,similarity:Belongs to the neuromodulin family.,similarity:Contains 1 IQ domain.,subcellular location:Cytoplasmic surface of growth cone and synaptic plasma membranes.,subunit:Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.,
Subcellular Location：Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, growth cone membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction, synapse . Cell projection, filopodium membrane ; Peripheral membrane protein . Perikaryon . Cell projection, dendrite . Cell projection, axon . Cytoplasm . Cytoplasmic surface of growth cone and synaptic plasma membranes. .
Expression： Alzheimer cortex,Brain,Subthalamic nucleus,
