Target：Uroplakin III

Fields：Bladder cancer

Gene Name：UPK3A UPK3

Protein Name：Uroplakin-3a (UP3a) (Uroplakin III) (UPIII)

Human Gene Id：7380

Human Swiss Prot No：O75631

Immunogen：Synthesized peptide derived from human Uroplakin III AA range: 200-287

Specificity：The antibody can specifically recognize human Uroplakin III protein.

Formulation：PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Source：Mouse, Monoclonal/IgG1, Lambda

Dilution：IHC 1:200-400. ELISA 1:500-5000

Purification：The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Observed Band(KD)：50-60kD

Background： This gene encodes a member of the uroplakin family, a group of transmembrane proteins that form complexes on the apical surface of the bladder epithelium. Mutations in this gene may be associated with renal adysplasia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009],

Function：disease:Defects in UPK3A are a cause of renal adysplasia [MIM:191830]; also known as renal agenesis or renal aplasia. Renal agenesis refers to the absence of one (unilateral) or both (bilateral) kidneys at birth. Bilateral renal agenesis belongs to a group of perinatally lethal renal diseases, including severe bilateral renal dysplasia, unilateral renal agenesis with contralateral dysplasia and severe obstructive uropathy.,function:Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence.,similarity:Belongs to the uroplakin-3 family.,subcellular location:Heterodimer formation

Subcellular Location：Membranous, Cytoplasmic

Expression：Expressed in ureter.