Target：Histone deacetylase 9
Fields：Neutrophil extracellular trap formation;Alcoholism;Viral carcinogenesis
Gene Name：HDAC9
Protein Name：Histone deacetylase 9
Human Gene Id：9734
Human Swiss Prot No：Q9UKV0-5,6,7
Immunogen：The antiserum was produced against synthesized peptide derived from human HDAC9. AA range:1017-1066
Specificity：Histone deacetylase 9 Polyclonal Antibody detects endogenous levels of Histone deacetylase 9 protein.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：Histone deacetylase 9;HD9;Histone deacetylase 7B;HD7;HD7b;Histone deacetylase-related protein;MEF2-interacting transcription repressor MITR;HDAC9;HDAC7;HDAC7B;HDRP;KIAA0744;MITR
Observed Band(KD)：110kD
Background：Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. Histone deacetylase 9 encoded by HDAC9 has sequence homology to members of the histone deacetylase family. HDAC9 is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined.
Subcellular Location：Nucleus .
Expression：Broadly expressed, with highest levels in brain, heart, muscle and testis. Isoform 3 is present in human bladder carcinoma cells (at protein level).
