Target：Histone H2B

Fields：Neutrophil extracellular trap formation;Alcoholism;Viral carcinogenesis;Systemic lupus erythematosus

Gene Name：HIST1H2BC

Protein Name：Histone H2B type 1-A/Histone H2B type 1-B/Histone H2B type 1-C/E/F/G/I

Human Gene Id：255626/3018/3017/8339/8343/8344/8346/8347

Human Swiss Prot No：Q96A08/P33778/P62807

Mouse Gene Id：319177/319178/319179

Rat Gene Id：24829

Rat Swiss Prot No：Q00729

Immunogen：Synthetic Peptide of Histone H2B (Mono Methyl Lys5)

Specificity：The antibody detects endogenous Histone H2B (Mono Methyl Lys5) protein.

Formulation：PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Source：Polyclonal, Mouse

Dilution：WB 1:500-1000

Purification：The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：H2BK5ME1;HIST1H2BA;TSH2B;Histone H2B type 1-A;Histone H2B, testis;Testis-specific histone H2B;HIST1H2BB;H2BFF;Histone H2B type 1-B;Histone H2B.1;Histone H2B.f;H2B/f;HIST1H2BC;H2BFL;HIST1H2BE;H2BFH;HIST1H2BF;H2BFG;HIST1H2BG;H2BFA;HIST1H2BI;H2BFK;Histone H2B type 1-C/E/F/G/I;Histone H2B.1 A;Histone H2B.a;H2B/a;Histone H2B.g;H2B/g;Histone H2B.h;H2B/h;Histone H2B.k;H2B/k;Histone H2B.l;H2B/l

Observed Band(KD)：14kD

Background： Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015],

Function：function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.,PTM:Monoubiquitination of Lys-122 by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II.,similarity:Belongs to the histone H2B family.,subunit:The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one

Subcellular Location：Nucleus . Chromosome .

Expression：Mainly expressed in testis, and the corresponding protein is also present in mature sperm (at protein level). Also found in some fat cells.