Target：SH-PTP2
Fields：Ras signaling pathway;Phospholipase D signaling pathway;Axon guidance;C-type lectin receptor signaling pathway;JAK-STAT signaling pathway;Natural killer cell mediated cytotoxicity;Leukocyte transendothelial migration;Neurotrophin signaling pathway;Adipocytokine signaling pathway;Insulin resistance;Epithelial cell signaling in Helicobacter pylori infection;Pathogenic Escherichia coli infection;Herpes simplex virus 1 infection;Proteoglycans in cancer;Chemical carcinogenesis - reactive oxygen species;Renal cell carcinoma;Chronic myeloid leukemia;PD-L1 expression and PD-1 checkpoint pathway in cancer
Gene Name：PTPN11
Protein Name：Tyrosine-protein phosphatase non-receptor type 11
Human Gene Id：5781
Human Swiss Prot No：Q06124
Mouse Gene Id：19247
Mouse Swiss Prot No：P35235
Rat Gene Id：25622
Rat Swiss Prot No：P41499
Immunogen：The antiserum was produced against synthesized peptide derived from human SHP-2 around the phosphorylation site of Tyr580. AA range:546-595
Specificity：Phospho-SH-PTP2 (Y580) Polyclonal Antibody detects endogenous levels of SH-PTP2 protein only when phosphorylated at Y580.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：PTPN11;PTP2C;SHPTP2;Tyrosine-protein phosphatase non-receptor type 11;Protein-tyrosine phosphatase 1D;PTP-1D;Protein-tyrosine phosphatase 2C;PTP-2C;SH-PTP2;SHP-2;Shp2;SH-PTP3
Observed Band(KD)：70kD
Background： The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016],
Function：catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,disease:Defects in PTPN11 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. It is characterized by leukocytosis with tissue infiltration and in vitro hypersensitivity of myeloid progenitors to granulocyte-macrophage colony stimulating factor.,disease:Defects in PTPN11 are a cause of Noonan-like syndrome [MIM:163955]; also known as Noonan-like/multiple giant cell lesion syndrome. It is an autosomal dominant disorder characterized by Noonan features associates with giant cell lesions of bone and soft tissue.,disease:Defects in PTPN11 are the cause of LEOPARD syndrome [MIM:151100]. It is an autosomal dominant disorder allelic with Noonan
Subcellular Location：Cytoplasm . Nucleus .
Expression：Widely expressed, with highest levels in heart, brain, and skeletal muscle.
