Target：Unc18-1
Fields：Synaptic vesicle cycle
Gene Name：STXBP1
Protein Name：Syntaxin-binding protein 1
Human Gene Id：6812
Human Swiss Prot No：P61764
Mouse Gene Id：20910
Mouse Swiss Prot No：O08599
Rat Gene Id：25558
Rat Swiss Prot No：P61765
Immunogen：The antiserum was produced against synthesized peptide derived from human MUNC-18a around the phosphorylation site of Ser313. AA range:279-328
Specificity：Phospho-Unc18-1 (S313) Polyclonal Antibody detects endogenous levels of Unc18-1 protein only when phosphorylated at S313.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：STXBP1;UNC18A;Syntaxin-binding protein 1;MUNC18-1;N-Sec1;Protein unc-18 homolog 1;Unc18-1;Protein unc-18 homolog A;Unc-18A;p67
Observed Band(KD)：65kD
Background： This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010],
Function：disease:Defects in STXBP1 are the cause of early infantile epileptic encephalopathy type 4 (EIEE4) [MIM:612164]. Affected individuals have neonatal or infantile onset of seizures, suppression-burst pattern on EEG, profound mental retardation, and MRI evidence of hypomyelination.,function:May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.,similarity:Belongs to the STXBP/unc-18/SEC1 family.,subunit:Binds SYTL4 and STX1A.,tissue specificity:Brain and spinal cord. Highly enriched in axons.,
Subcellular Location：Cytoplasm, cytosol . Membrane; Peripheral membrane protein.
Expression：Brain and spinal cord. Highly enriched in axons.
