Target：c-Myc
Fields：MAPK signaling pathway;ErbB signaling pathway;Cell cycle;PI3K-Akt signaling pathway;Cellular senescence;Wnt signaling pathway;TGF-beta signaling pathway;Hippo signaling pathway;Signaling pathways regulating pluripotency of stem cells;JAK-STAT signaling pathway;Thyroid hormone signaling pathway;Salmonella infection;Hepatitis C;Hepatitis B;Human cytomegalovirus infection;Human T-cell leukemia virus 1 infection;Kaposi sarcoma-associated herpesvirus infection;Epstein-Barr virus infection;Pathways in cancer;Transcriptional misregulation in cancer;Proteoglycans in cancer;MicroRNAs in cancer;Chemical carcinogenesis - receptor activation;Colorectal cancer;Endometrial cancer;Thyroid cancer;Bladder cancer;Chronic myeloid leukemia;Acute myeloid leukemia;Small cell lung cancer;Breast cancer;Hepatocellular carcinoma;Gastric cancer;Central carbon metabolism in cancer
Gene Name：MYC
Protein Name：Myc proto-oncogene protein
Human Gene Id：4609
Human Swiss Prot No：P01106
Mouse Gene Id：17869
Mouse Swiss Prot No：P01108
Rat Gene Id：24577
Rat Swiss Prot No：P09416
Immunogen：The antiserum was produced against synthesized peptide derived from human Myc around the phosphorylation site of Thr58. AA range:25-74
Specificity：Phospho-c-Myc (T58) Polyclonal Antibody detects endogenous levels of c-Myc protein only when phosphorylated at T58.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. Immunoprecipitation: 2-5 ug:mg lysate. ELISA: 1:10000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：MYC;BHLHE39;Myc proto-oncogene protein;Class E basic helix-loop-helix protein 39;bHLHe39;Proto-oncogene c-Myc;Transcription factor p64
Observed Band(KD)：50,(also ~60KD in some samples)
Background： The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008],
Function：disease:A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.,disease:Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors.,function:Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.,online information:Myc entry,PTM:Phosphorylated by PRKDC.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B.,
Subcellular Location：Nucleus, nucleoplasm . Nucleus, nucleolus .
Expression： Cervix,Epithelium,Leukemia,Placenta,Promyelocytic l
