Target：cGKII
Fields：cGMP-PKG signaling pathway;Gap junction;Platelet activation;Circadian entrainment;Thermogenesis;Long-term depression;Olfactory transduction;Regulation of lipolysis in adipocytes;Renin secretion;Salivary secretion
Gene Name：PRKG2
Protein Name：cGMP-dependent protein kinase 2
Human Gene Id：5593
Human Swiss Prot No：Q13237
Mouse Swiss Prot No：Q61410
Rat Gene Id：25523
Rat Swiss Prot No：Q64595
Immunogen：The antiserum was produced against synthesized peptide derived from human PKG2 around the phosphorylation site of Ser126. AA range:92-141
Specificity：Phospho-cGKII (S126) Polyclonal Antibody detects endogenous levels of cGKII protein only when phosphorylated at S126.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：PRKG2;PRKGR2;cGMP-dependent protein kinase 2;cGK 2;cGK2;cGMP-dependent protein kinase II;cGKII
Molecular Weight(Da)：87kD
Background： This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],
Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Binding of cGMP results in enzyme activation.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 cyclic nucleotide-binding domains.,tissue specificity:Highly concentrated in brain, lung and intestinal mucosa.,
Subcellular Location：Apical cell membrane ; Lipid-anchor .
Expression：Highly concentrated in brain, lung and intestinal mucosa.
