Target：c-Fms

Fields：MAPK signaling pathway;Ras signaling pathway;Rap1 signaling pathway;Cytokine-cytokine receptor interaction;Viral protein interaction with cytokine and cytokine receptor;PI3K-Akt signaling pathway;Osteoclast differentiation;Hematopoietic cell lineage;Pathways in cancer;Transcriptional misregulation in cancer;Acute myeloid leukemia

Gene Name：CSF1R

Protein Name：Macrophage colony-stimulating factor 1 receptor

Human Gene Id：1436

Human Swiss Prot No：P07333

Mouse Gene Id：12978

Mouse Swiss Prot No：P09581

Rat Swiss Prot No：Q00495

Immunogen：Synthesized phospho-peptide around the phosphorylation site of human c-Fms (phospho Tyr708)

Specificity：Phospho-c-Fms (Y708) Polyclonal Antibody detects endogenous levels of c-Fms protein only when phosphorylated at Y708.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CSF1R;FMS;Macrophage colony-stimulating factor 1 receptor;CSF-1 receptor;CSF-1-R;CSF-1R;M-CSF-R;Proto-oncogene c-Fms;CD antigen CD115

Observed Band(KD)：130-170kD

Background： The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],

Function：catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Protein tyrosine-kinase transmembrane receptor for CSF1 and IL34.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Interacts with INPPL1/SHIP2 and THOC5.,tissue specificity:Expressed in bone marrow and in differentiated blood mononuclear cells.,

Subcellular Location：Cell membrane; Single-pass type I membrane protein.

Expression：Expressed in bone marrow and in differentiated blood mononuclear cells.