Target：CD88
Fields：Neuroactive ligand-receptor interaction;Complement and coagulation cascades;Neutrophil extracellular trap formation;Alcoholic liver disease;Staphylococcus aureus infection;Coronavirus disease - COVID-19
Gene Name：C5AR1
Protein Name：C5a anaphylatoxin chemotactic receptor
Human Gene Id：728
Human Swiss Prot No：P21730
Mouse Swiss Prot No：P30993
Immunogen：The antiserum was produced against synthesized peptide derived from human CD88/C5aR around the phosphorylation site of Ser338. AA range:301-350
Specificity：Phospho-CD88 (S338) Polyclonal Antibody detects endogenous levels of CD88 protein only when phosphorylated at S338.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：C5AR1;C5AR;C5R1;C5a anaphylatoxin chemotactic receptor;C5a-R;C5aR;CD antigen CD88
Molecular Weight(Da)：39kD
Background：function:Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.,PTM:Sulfation plays a critical role in the association of the receptor with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist.,similarity:Belongs to the G-protein coupled receptor 1 family.,
Function：function:Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.,PTM:Sulfation plays a critical role in the association of the receptor with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist.,similarity:Belongs to the G-protein coupled receptor 1 family.,
Subcellular Location：Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle . Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles. .
Expression： Brain,
