Target：CD28
Fields：Cell adhesion molecules;T cell receptor signaling pathway;Intestinal immune network for IgA production;Type I diabetes mellitus;Measles;PD-L1 expression and PD-1 checkpoint pathway in cancer;Autoimmune thyroid disease;Systemic lupus erythematosus;Rheumatoid arthritis;Allograft rejection;Graft-versus-host disease;Viral myocarditis
Gene Name：CD28
Protein Name：T-cell-specific surface glycoprotein CD28
Human Gene Id：940
Human Swiss Prot No：P10747
Mouse Gene Id：12487
Mouse Swiss Prot No：P31041
Immunogen：The antiserum was produced against synthesized peptide derived from human CD28 around the phosphorylation site of Tyr218. AA range:171-220
Specificity：Phospho-CD28 (Y218) Polyclonal Antibody detects endogenous levels of CD28 protein only when phosphorylated at Y218.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：CD28;T-cell-specific surface glycoprotein CD28;TP44;CD antigen CD28
Observed Band(KD)：45kD
Background： The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011],
Function：function:Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.,online information:CD28 entry,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70.,tissue specificity:Expressed in T-cells and plasma cells, but not in less mature B-cells.,
Subcellular Location：Membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell surface .
Expression：Expressed in T-cells and plasma cells, but not in less mature B-cells.
