Target：CD19
Fields：PI3K-Akt signaling pathway;Hematopoietic cell lineage;B cell receptor signaling pathway;Epstein-Barr virus infection;Primary immunodeficiency
Gene Name：CD19
Protein Name：B-lymphocyte antigen CD19
Human Gene Id：930
Human Swiss Prot No：P15391
Mouse Gene Id：12478
Mouse Swiss Prot No：P25918
Immunogen：The antiserum was produced against synthesized peptide derived from human CD19 around the phosphorylation site of Tyr531. AA range:501-550
Specificity：Phospho-CD19 (Y531) Polyclonal Antibody detects endogenous levels of CD19 protein only when phosphorylated at Y531.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：CD19;B-lymphocyte antigen CD19;B-lymphocyte surface antigen B4;Differentiation antigen CD19;T-cell surface antigen Leu-12;CD antigen CD19
Observed Band(KD)：61kD
Background： Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008],
Function：disease:Defects in CD19 are a cause of hypogammaglobulinemia [MIM:107265].,function:Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.,online information:CD19 mutation db,PTM:Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409.,
Subcellular Location：Cell membrane ; Single-pass type I membrane protein . Membrane raft ; Single-pass type I membrane protein .
Expression：Detected on marginal zone and germinal center B cells in lymph nodes (PubMed:2463100). Detected on blood B cells (at protein level) (PubMed:2463100, PubMed:16672701).
