Target：MAP4
Gene Name：MAP4
Protein Name：Microtubule-associated protein 4
Human Gene Id：4134
Human Swiss Prot No：P27816
Mouse Gene Id：17758
Mouse Swiss Prot No：P27546
Rat Gene Id：367171
Rat Swiss Prot No：Q5M7W5
Immunogen：The antiserum was produced against synthesized peptide derived from human MAP4 around the phosphorylation site of Ser696. AA range:662-711
Specificity：Phospho-MAP-4 (S696) Polyclonal Antibody detects endogenous levels of MAP-4 protein only when phosphorylated at S696.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：MAP4;Microtubule-associated protein 4;MAP-4
Molecular Weight(Da)：121kD
Observed Band(KD)：121kD
Background： The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],
Function：alternative products:Additional isoforms seem to exist,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Non-neuronal microtubule-associated protein. Promotes microtubule assembly.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). Phosphorylation on Ser-787 negatively regulates MAP4 activity to promote microtubule assembly. Isoform 3 is phosphorylated on Ser-337 and Ser-338.,similarity:Contains 3 Tau/MAP repeats.,similarity:Contains 4 Tau/MAP repeats.,
Subcellular Location：Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center . Recruitment to microtubule is inhibited by microtubules polyglutamylation. .
Expression： Bone marrow,Brain,Cerebellum,Colon carcinoma,Epithelium,Eye,Heart,Liver,Lym
