Target：C/EBP α

Fields：Non-alcoholic fatty liver disease;Pathways in cancer;Transcriptional misregulation in cancer;Acute myeloid leukemia

Gene Name：CEBPA

Protein Name：CCAAT/enhancer-binding protein alpha

Human Gene Id：1050

Human Swiss Prot No：P49715

Mouse Gene Id：12606

Mouse Swiss Prot No：P53566

Rat Gene Id：24252

Rat Swiss Prot No：P05554

Immunogen：Synthesized phospho-peptide around the phosphorylation site of human C/EBP α (phospho Thr230)

Specificity：Phospho-C/EBP α (T230) Polyclonal Antibody detects endogenous levels of C/EBP α protein only when phosphorylated at T230.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：CEBPA;CCAAT/enhancer-binding protein alpha;C/EBP alpha

Observed Band(KD)：42,also have 30kd isform

Background： This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013],

Function：function:C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. C/EBP subfamily.,similarity:Contains 1 bZIP domain.,subunit:Binds DNA as a dimer and can form stable heterodimers with C/EBP beta and gamma. Interacts with UBN1. Interacts with HBV protein X.,

Subcellular Location：Nucleus .; [Isoform 4]: Nucleus, nucleolus .

Expression： Liver,Pancreas,Umbilical cord,White Matter pool- 5 brain tissues- f