Target：EPHA7

Fields：Axon guidance

Gene Name：EPHA7

Protein Name：Ephrin type-A receptor 7

Human Gene Id：2045

Human Swiss Prot No：Q15375

Mouse Gene Id：13841

Mouse Swiss Prot No：Q61772

Rat Gene Id：171287

Rat Swiss Prot No：P54759

Immunogen：Synthesized phospho-peptide around the phosphorylation site of human EphA7 (phospho Tyr791)

Specificity：Phospho-EphA7 (Y791) Polyclonal Antibody detects endogenous levels of EphA7 protein only when phosphorylated at Y791.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：EPHA7;EHK3;HEK11;Ephrin type-A receptor 7;EPH homology kinase 3;EHK-3;EPH-like kinase 11;EK11;hEK11

Observed Band(KD)：112kD

Background： This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],

Function：catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A2, -A3, -A4 and -A5.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:Interacts with PRKCABP and GRIP1.,tissue specificity:Widely expressed.,

Subcellular Location：Cell membrane ; Single-pass type I membrane protein .

Expression：Widely expressed.