Target：eIF4B
Fields：mTOR signaling pathway;PI3K-Akt signaling pathway;Proteoglycans in cancer
Gene Name：EIF4B
Protein Name：Eukaryotic translation initiation factor 4B
Human Gene Id：3716
Human Swiss Prot No：P23588
Mouse Gene Id：75705
Mouse Swiss Prot No：Q8BGD9
Immunogen：The antiserum was produced against synthesized peptide derived from human eIF4B around the phosphorylation site of Ser422. AA range:388-437
Specificity：Phospho-eIF4B (S422) Polyclonal Antibody detects endogenous levels of eIF4B protein only when phosphorylated at S422.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：EIF4B;Eukaryotic translation initiation factor 4B;eIF-4B
Observed Band(KD)：80kD
Background：function:Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Self-associates and interacts with EIF3 p170 subunit.,
Function：function:Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Self-associates and interacts with EIF3 p170 subunit.,
Subcellular Location：cytosol,polysome,eukaryotic translation initiation factor 4F complex,dendrite,neuronal cell body,
Expression： Adipose tissue,Brain,Cervix carcinoma,Epithelium,Liver,Lung
