Target：Rsk-1
Fields：MAPK signaling pathway;Oocyte meiosis;mTOR signaling pathway;Thermogenesis;Long-term potentiation;Neurotrophin signaling pathway;Progesterone-mediated oocyte maturation;Insulin resistance;Yersinia infection;Chemical carcinogenesis - receptor activation
Gene Name：RPS6KA1
Protein Name：Ribosomal protein S6 kinase alpha-1
Human Gene Id：6195
Human Swiss Prot No：Q15418
Mouse Swiss Prot No：P18653
Rat Gene Id：81771
Rat Swiss Prot No：Q63531
Immunogen：The antiserum was produced against synthesized peptide derived from human p90 RSK around the phosphorylation site of Thr573. AA range:539-588
Specificity：Phospho-Rsk-1 (T573) Polyclonal Antibody detects endogenous levels of Rsk-1 protein only when phosphorylated at T573.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：RPS6KA1;MAPKAPK1A;RSK1;Ribosomal protein S6 kinase alpha-1;S6K-alpha-1;90 kDa ribosomal protein S6 kinase 1;p90-RSK 1;p90RSK1;p90S6K;MAP kinase-activated protein kinase 1a;MAPK-activated protein kinase 1a;MAPKAP kinase 1a;MAPKAP
Observed Band(KD)：95kD
Background：ribosomal protein S6 kinase A1(RPS6KA1) Homo sapiens This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],
Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,cofactor:Magnesium.,enzyme regulation:Activated by multiple phosphorylations on threonine and serine residues.,function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.,PTM:Autophosphorylated on Ser-380, as part of the activation process.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 2 protein kinase domains.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic s
Subcellular Location：Nucleus. Cytoplasm.
Expression： Colon,Epithelium,
