Target：Arrestin 1
Fields：MAPK signaling pathway;Chemokine signaling pathway;Endocytosis;Hedgehog signaling pathway;Dopaminergic synapse;Olfactory transduction;Relaxin signaling pathway;Parathyroid hormone synthesis, secretion and action;GnRH secretion;Morphine addiction;Chemical carcinogenesis - receptor activation
Gene Name：ARRB1
Protein Name：Beta-arrestin-1
Human Gene Id：408
Human Swiss Prot No：P49407
Mouse Swiss Prot No：Q8BWG8
Immunogen：The antiserum was produced against synthesized peptide derived from human Arrestin 1 around the phosphorylation site of Ser412. AA range:369-418
Specificity：Phospho-Arrestin-β-1 (S412) Polyclonal Antibody detects endogenous levels of Arrestin-β-1 protein only when phosphorylated at S412.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：ARRB1;ARR1;Beta-arrestin-1;Arrestin beta-1
Observed Band(KD)：47kD
Background： Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011],
Function：function:Regulates beta-adrenergic receptor function. Beta-arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate G(S) proteins.,online information:Arrestin entry,similarity:Belongs to the arrestin family.,
Subcellular Location：Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit . Cell projection, pseudopodium . Cytoplasmic vesicle. Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. The monomeric form is predominantly located in the nucleus. The oligomeric form is located in the cytoplasm. Translocates to the nucleus upon stimulation of OPRD1 (By similarity). .
Expression： Brain,Peripheral blood,Uterus,
