Target：APC1
Fields：Cell cycle;Oocyte meiosis;Ubiquitin mediated proteolysis;Progesterone-mediated oocyte maturation;Human T-cell leukemia virus 1 infection
Gene Name：ANAPC1
Protein Name：Anaphase-promoting complex subunit 1
Human Gene Id：64682
Human Swiss Prot No：Q9H1A4
Mouse Gene Id：17222
Mouse Swiss Prot No：P53995
Immunogen：The antiserum was produced against synthesized peptide derived from human APC1 around the phosphorylation site of Ser355. AA range:321-370
Specificity：Phospho-APC1 (S355) Polyclonal Antibody detects endogenous levels of APC1 protein only when phosphorylated at S355.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：ANAPC1;TSG24;Anaphase-promoting complex subunit 1;APC1;Cyclosome subunit 1;Mitotic checkpoint regulator;Testis-specific gene 24 protein
Molecular Weight(Da)：217kD
Background： This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011],
Function：function:Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated. Phosphorylation on Ser-355 occurs specifically during mitosis.,similarity:Belongs to the APC1 family.,similarity:Contains 4 PC repeats.,subunit:The APC/C is composed of at least 11 subunits.,
Subcellular Location：nucleoplasm,anaphase-promoting complex,cytosol,
Expression： Colon,Epithelium,Ovary,Placenta,
