Target：Crk-L
Fields：MAPK signaling pathway;ErbB signaling pathway;Rap1 signaling pathway;Chemokine signaling pathway;Focal adhesion;Fc gamma R-mediated phagocytosis;Neurotrophin signaling pathway;Regulation of actin cytoskeleton;Insulin signaling pathway;Growth hormone synthesis, secretion and action;Bacterial invasion of epithelial cells;Shigellosis;Yersinia infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Pathways in cancer;MicroRNAs in cancer;Renal cell carcinoma;Chronic myeloid leukemia
Gene Name：CRKL
Protein Name：Crk-like protein
Human Gene Id：1399
Human Swiss Prot No：P46109
Mouse Gene Id：12929
Mouse Swiss Prot No：P47941
Rat Gene Id：1.00911e+008
Rat Swiss Prot No：Q5U2U2
Immunogen：The antiserum was produced against synthesized peptide derived from human CrkL around the phosphorylation site of Tyr207. AA range:173-222
Specificity：Phospho-Crk-L (Y207) Polyclonal Antibody detects endogenous levels of Crk-L protein only when phosphorylated at Y207.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：CRKL;Crk-like protein
Observed Band(KD)：39kD
Background： This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009],
Function：function:May mediate the transduction of intracellular signals.,similarity:Contains 1 SH2 domain.,similarity:Contains 2 SH3 domains.,subunit:Interacts with INPP5D/SHIP1. Interacts with DOCK2 and EPOR. Interacts with phosphorylated CBLB and IRS4.,
Subcellular Location：endosome,cytosol,cell-cell adherens junction,extracellular exosome,
Expression： Skin,Spleen,
