Target：Integrin β3
Fields：Rap1 signaling pathway;Phagosome;PI3K-Akt signaling pathway;Osteoclast differentiation;Focal adhesion;ECM-receptor interaction;Platelet activation;Neutrophil extracellular trap formation;Hematopoietic cell lineage;Regulation of actin cytoskeleton;Thyroid hormone signaling pathway;Human cytomegalovirus infection;Human papillomavirus infection;Herpes simplex virus 1 infection;Proteoglycans in cancer;MicroRNAs in cancer;Hypertrophic cardiomyopathy;Arrhythmogenic right ventricular cardiomyopathy;Dilated cardiomyopathy;Fluid shear stress and atherosclerosis
Gene Name：ITGB3
Protein Name：Integrin beta-3
Human Gene Id：3690
Human Swiss Prot No：P05106
Mouse Gene Id：16416
Mouse Swiss Prot No：O54890
Immunogen：The antiserum was produced against synthesized peptide derived from human Integrin beta3 around the phosphorylation site of Tyr785. AA range:739-788
Specificity：Phospho-Integrin β3 (Y785) Polyclonal Antibody detects endogenous levels of Integrin β3 protein only when phosphorylated at Y785.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：IF ICC 1:50-300; ELISA 1:2000-20000; IHC 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：ITGB3;GP3A;Integrin beta-3;Platelet membrane glycoprotein IIIa;GPIIIa;CD antigen CD61
Observed Band(KD)：87kD
Background： The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008],
Function：disease:Defects in ITGB3 are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. Its inheritance is autosomal recessive. It is characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT variants have normal or near normal (60-100%) expression of dysfunctional receptors.,function:Int
Subcellular Location：Cell membrane ; Single-pass type I membrane protein . Cell projection, lamellipodium membrane . Cell junction, focal adhesion . Cell junction, synapse, postsynaptic cell membrane ; Single-pass type I membrane protein . Cell junction, synapse .
Expression：Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.
