Target：Integrin β2
Fields：Rap1 signaling pathway;Phagosome;Hippo signaling pathway;Cell adhesion molecules;Complement and coagulation cascades;Neutrophil extracellular trap formation;Natural killer cell mediated cytotoxicity;Leukocyte transendothelial migration;Regulation of actin cytoskeleton;Pertussis;Legionellosis;Leishmaniasis;Malaria;Amoebiasis;Staphylococcus aureus infection;Tuberculosis;Human T-cell leukemia virus 1 infection;Rheumatoid arthritis;Viral myocarditis
Gene Name：ITGB2
Protein Name：Integrin beta-2
Human Gene Id：3689
Human Swiss Prot No：P05107
Mouse Gene Id：16414
Mouse Swiss Prot No：P11835
Immunogen：The antiserum was produced against synthesized peptide derived from human CD18/ITGB2 around the phosphorylation site of Thr758. AA range:720-769
Specificity：Phospho-Integrin β2 (T758) Polyclonal Antibody detects endogenous levels of Integrin β2 protein only when phosphorylated at T758.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000;IHC 1:50-300
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：ITGB2;CD18;MFI7;Integrin beta-2;Cell surface adhesion glycoproteins LFA-1/CR3/p150;95 subunit beta;Complement receptor C3 subunit beta;CD antigen CD18
Observed Band(KD)：170kD
Background： This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],
Function：disease:Defects in ITGB2 are the cause of leukocyte adhesion deficiency type I (LAD1) [MIM:116920]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.,function:Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.,online information:ITGB2 mutation db,PTM:Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters. Phosphorylation on Thr-758 (but not on S
Subcellular Location：Cell membrane ; Single-pass type I membrane protein . Membrane raft ; Single-pass type I membrane protein .
Expression：Leukocytes (PubMed:23775590). Expressed in neutrophils (at protein level) (PubMed:21193407, PubMed:28807980).
