Target：IL-3Rβ
Fields：Cytokine-cytokine receptor interaction;Apoptosis;JAK-STAT signaling pathway;Pathways in cancer
Gene Name：CSF2RB
Protein Name：Cytokine receptor common subunit beta
Human Gene Id：1439
Human Swiss Prot No：P32927
Mouse Gene Id：12983
Mouse Swiss Prot No：P26955
Immunogen：The antiserum was produced against synthesized peptide derived from human IL-3R beta around the phosphorylation site of Tyr593. AA range:559-608
Specificity：Phospho-IL-3Rβ (Y593) Polyclonal Antibody detects endogenous levels of IL-3Rβ protein only when phosphorylated at Y593.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：CSF2RB;IL3RB;IL5RB;Cytokine receptor common subunit beta;CDw131;GM-CSF/IL-3/IL-5 receptor common beta subunit;CD antigen CD131
Observed Band(KD)：125kD
Background： The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008],
Function：disease:Defects in CSF2RB are a cause of congenital pulmonary alveolar proteinosis (PAP) [MIM:265120]. PAP is an autosomal recessive fatal respiratory disease.,domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.,similarity:Belongs to the type I cytokine receptor family. Type 4 subfamily.,similarity:Contains 2 fibronectin type-III domains.,subunit:Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors.,
Subcellular Location：Membrane; Single-pass type I membrane protein.
Expression： Placenta,
