Target：GluR4
Fields：cAMP signaling pathway;Neuroactive ligand-receptor interaction;Circadian entrainment;Retrograde endocannabinoid signaling;Glutamatergic synapse;Dopaminergic synapse;Huntington disease;Pathways of neurodegeneration - multiple diseases;Amphetamine addiction;Nicotine addiction
Gene Name：GRIA4
Protein Name：Glutamate receptor 4
Human Gene Id：2893
Human Swiss Prot No：P48058
Mouse Gene Id：14802
Mouse Swiss Prot No：Q9Z2W8
Rat Gene Id：29629
Rat Swiss Prot No：P19493
Immunogen：The antiserum was produced against synthesized peptide derived from human GluR4 around the phosphorylation site of Ser862. AA range:828-877
Specificity：Phospho-GluR4 (S862) Polyclonal Antibody detects endogenous levels of GluR4 protein only when phosphorylated at S862.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：GRIA4;GLUR4;Glutamate receptor 4;GluR-4;GluR4;AMPA-selective glutamate receptor 4;GluR-D;Glutamate receptor ionotropic; AMPA 4;GluA4
Observed Band(KD)：100kD
Background： Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia. [provided by RefSeq, Jul 2008],
Function：function:Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.,miscellaneous:The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.,PTM:Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regul
Subcellular Location：Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Interaction with CNIH2, CNIH3 and PRKCG promotes cell surface expression. .
Expression： Brain,Donated clones,PCR rescued clones,
