Target：GluR-1
Fields：cAMP signaling pathway;Neuroactive ligand-receptor interaction;Circadian entrainment;Long-term potentiation;Retrograde endocannabinoid signaling;Glutamatergic synapse;Dopaminergic synapse;Long-term depression;Amyotrophic lateral sclerosis;Huntington disease;Spinocerebellar ataxia;Pathways of neurodegeneration - multiple diseases;Amphetamine addiction;Nicotine addiction
Gene Name：GRIA1
Protein Name：Glutamate receptor 1
Human Gene Id：2890
Human Swiss Prot No：P42261
Mouse Gene Id：14799
Mouse Swiss Prot No：P23818
Rat Gene Id：50592
Rat Swiss Prot No：P19490
Immunogen：The antiserum was produced against synthesized peptide derived from human GluR1 around the phosphorylation site of Ser863. AA range:829-878
Specificity：Phospho-GluR-1 (S863) Polyclonal Antibody detects endogenous levels of GluR-1 protein only when phosphorylated at S863.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：GRIA1;GLUH1;GLUR1;Glutamate receptor 1;GluR-1;AMPA-selective glutamate receptor 1;GluR-A;GluR-K1;Glutamate receptor ionotropic; AMPA 1;GluA1
Observed Band(KD)：102kD
Background： Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function：function:Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.,miscellaneous:The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.,PTM:Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regul
Subcellular Location：Cell membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic density membrane ; Multi-pass membrane protein . Cell projection, dendrite . Cell projection, dendritic spine . Early endosome membrane ; Multi-pass membrane protein . Recycling endosome membrane ; Multi-pass membrane protein . Cell junction, synapse, presynapse . Cell junction, synapse . Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. Colocalizes with PDLIM4 in early endosomes. Displays a somatodendritic localization and is excluded from axons in neurons (By similarity). Localized to cone photoreceptor pedicles (By similarity). .
Expression：Widely expressed in brain.
