Target：RIP2
Fields：NOD-like receptor signaling pathway;Neurotrophin signaling pathway;Shigellosis;Salmonella infection;Tuberculosis
Gene Name：RIPK2
Protein Name：Receptor-interacting serine/threonine-protein kinase 2
Human Gene Id：8767
Human Swiss Prot No：O43353
Mouse Gene Id：192656
Mouse Swiss Prot No：P58801
Immunogen：The antiserum was produced against synthesized peptide derived from human RIPK2 around the phosphorylation site of Ser176. AA range:146-195
Specificity：Phospho-RIP2 (S176) Polyclonal Antibody detects endogenous levels of RIP2 protein only when phosphorylated at S176.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：RIPK2;CARDIAK;RICK;RIP2;Receptor-interacting serine/threonine-protein kinase 2;CARD-containing interleukin-1 beta-converting enzyme-associated kinase;CARD-containing IL-1 beta ICE-kinase;RIP-like-interacting CLARP kinase;Receptor-in
Observed Band(KD)：70kD
Background： This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008],
Function：catalytic activity:ATP + a protein = ADP + a phosphoprotein.,function:Activates pro-caspase-1 and pro-caspase-8. Potentiates CASP8-mediated apoptosis. Activates NF-kappa-B.,PTM:Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.,similarity:Contains 1 CARD domain.,similarity:Contains 1 protein kinase domain.,subunit:Binds to CFLAR/CLARP and CASP1 via their CARD domains. Binds to BIRC3/c-IAP1 and BIRC2/c-IAP2, TRAF1, TRAF2, TRAF5 and TRAF6. May be a component of both the TNFRSF1A and TNRFSF5/CD40 receptor complex.,tissue specificity:Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.,
Subcellular Location：Cytoplasm .
Expression：Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.
