Target：NFAT5
Gene Name：NFAT5
Protein Name：Nuclear factor of activated T-cells 5
Human Gene Id：10725
Human Swiss Prot No：O94916
Mouse Swiss Prot No：Q9WV30
Immunogen：The antiserum was produced against synthesized peptide derived from human NFAT5 around the phosphorylation site of Ser1197. AA range:1171-1220
Specificity：Phospho-NFAT5 (S1197) Polyclonal Antibody detects endogenous levels of NFAT5 protein only when phosphorylated at S1197.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500-2000;IHC 1:50-300
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：NFAT5;KIAA0827;TONEBP;Nuclear factor of activated T-cells 5;NF-AT5;T-cell transcription factor NFAT5;Tonicity-responsive enhancer-binding protein;TonE-binding protein;TonEBP
Molecular Weight(Da)：166kD
Background： The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function：alternative products:Experimental confirmation may be lacking for some isoforms,function:Plays a role in the inducible expression of genes. Regulates hypertonicity-induced cellular accumulation of osmolytes.,similarity:Contains 1 RHD (Rel-like) domain.,subunit:Does not bind with Fos and Jun transcription factors. But might be capable of forming stable dimers with DNA elements.,tissue specificity:Highest levels in skeletal muscle, brain, heart and peripheral blood leukocytes. Also expressed in placenta, lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon.,
Subcellular Location：Nucleus . Cytoplasm . Nuclear distribution increases under hypertonic conditions. .
Expression：Widely expressed, with highest levels in skeletal muscle, brain, heart and peripheral blood leukocytes.
