Target：Rho GDIα

Fields：Neurotrophin signaling pathway;Vasopressin-regulated water reabsorption

Gene Name：ARHGDIA

Protein Name：Rho GDP-dissociation inhibitor 1

Human Gene Id：396

Human Swiss Prot No：P52565

Mouse Gene Id：192662

Mouse Swiss Prot No：Q99PT1

Rat Gene Id：360678

Rat Swiss Prot No：Q5XI73

Immunogen：The antiserum was produced against synthesized peptide derived from human ARHGDIA around the phosphorylation site of Ser174. AA range:140-189

Specificity：Phospho-Rho GDIα (S174) Polyclonal Antibody detects endogenous levels of Rho GDIα protein only when phosphorylated at S174.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：ARHGDIA;GDIA1;Rho GDP-dissociation inhibitor 1;Rho GDI 1;Rho-GDI alpha

Observed Band(KD)：23kD

Background： This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],

Function：function:Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.,similarity:Belongs to the Rho GDI family.,subunit:Monomer.,

Subcellular Location：Cytoplasm .

Expression： Brain,Cajal-Retzius cell,Colon,Epithelium,Fetal brain cortex,Lung,M