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PAKγ (phospho Ser141) Polyclonal Antibody
PAKγ (phospho Ser141) Polyclonal Antibody
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PAKγ (phospho Ser141) Polyclonal Antibody
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商品属性

Target:PAK2

Fields:MAPK signaling pathway;ErbB signaling pathway;Ras signaling pathway;Axon guidance;Focal adhesion;T cell receptor signaling pathway;Regulation of actin cytoskeleton;Pathogenic Escherichia coli infection;Human immunodeficiency virus 1 infection;Renal cell carcinoma

Gene Name:PAK2

Protein Name:Serine/threonine-protein kinase PAK 2

Human Gene Id:5062

Human Swiss Prot No:Q13177

Mouse Gene Id:224105

Mouse Swiss Prot No:Q8CIN4

Rat Gene Id:1.00911e+008

Rat Swiss Prot No:Q64303

Immunogen:The antiserum was produced against synthesized peptide derived from human PAK2 around the phosphorylation site of Ser141. AA range:107-156

Specificity:Phospho-PAKγ (S141) Polyclonal Antibody detects endogenous levels of PAKγ protein only when phosphorylated at S141.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source:Polyclonal, Rabbit,IgG

Dilution:WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration:1 mg/ml

Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name:PAK2;Serine/threonine-protein kinase PAK 2;Gamma-PAK;PAK65;S6/H4 kinase;p21-activated kinase 2;PAK-2;p58

Observed Band(KD):60kD

Background: The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. [provided by RefSeq, Jul 2008],

Function:catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-402 and allows the kinase domain to adopt an active structure (By similarity). Following caspase cleavage, autophosphorylted PAK-2p34 is constitutively active.,function:The activated kinase acts on a variety of targets. Phosphorylates ribosomal protein S6, histone H4 and myelin basic protein. Full length PAK 2 stimulates cell survival and cell growth. The process is, at least in part, mediated by phosphorylation and inhibition of pro-apoptotic BAD. Caspase-activated PAK-2p34 is involved in cell death response, probably involving the JNK signaling pathway. Cleaved PAK-2p34 seems to have a higher activity than the CDC42-activated for

Subcellular Location:[Serine/threonine-protein kinase PAK 2]: Cytoplasm. MYO18A mediates the cellular distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane.; [PAK-2p34]: Nucleus. Cytoplasm, perinuclear region. Membrane; Lipid-anchor. Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region. Myristoylation changes PAK-2p34 location to the membrane.

Expression:Ubiquitously expressed. Higher levels seen in skeletal muscle, ovary, thymus and spleen.

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