Target:PDGF Receptor α
Fields:EGFR tyrosine kinase inhibitor resistance;MAPK signaling pathway;Ras signaling pathway;Rap1 signaling pathway;Calcium signaling pathway;Phospholipase D signaling pathway;Endocytosis;PI3K-Akt signaling pathway;Focal adhesion;Gap junction;JAK-STAT signaling pathway;Regulation of actin cytoskeleton;Human cytomegalovirus infection;Pathways in cancer;MicroRNAs in cancer;Glioma;Prostate cancer;Melanoma;Central carbon metabolism in cancer;Choline metabolism in cancer
Gene Name:PDGFRA
Protein Name:Platelet-derived growth factor receptor alpha
Human Gene Id:5156
Human Swiss Prot No:P16234
Mouse Gene Id:18595
Mouse Swiss Prot No:P26618
Rat Gene Id:25267
Rat Swiss Prot No:P20786
Immunogen:The antiserum was produced against synthesized peptide derived from human PDGFR alpha around the phosphorylation site of Tyr762. AA range:731-780
Specificity:Phospho-PDGFR-α (Y762) Polyclonal Antibody detects endogenous levels of PDGFR-α protein only when phosphorylated at Y762.
Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source:Polyclonal, Rabbit,IgG
Dilution:IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:1 mg/ml
Storage Stability:-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name:PDGFRA;PDGFR2;RHEPDGFRA;Platelet-derived growth factor receptor alpha;PDGF-R-alpha;PDGFR-alpha;Alpha platelet-derived growth factor receptor;Alpha-type platelet-derived growth factor receptor;CD140 antigen-like family member A;CD14
Molecular Weight(Da):123kD
Background: This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012],
Function:catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:A fusion of PDGFRA and FIP1L1 (FIP1L1-PDGFRA), due to an interstitial chromosomal deletion, is the cause of some cases of hypereosinophilic syndrome (HES) [MIM:607685]. HES is a rare hematologic disorder characterized by sustained overproduction of eosinophils in the bone marrow, eosinophilia, tissue infiltration and organ damage.,function:Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Homodimer, and heterodimer with PDGFRB. Interacts with the SH2 domain of SHB via phosphorylated Tyr-720 (By similarity). Interacts with the S
Subcellular Location:Cell membrane ; Single-pass type I membrane protein . Cell projection, cilium . Golgi apparatus .
Expression:Detected in platelets (at protein level). Widely expressed. Detected in brain, fibroblasts, smooth muscle, heart, and embryo. Expressed in primary and metastatic colon tumors and in normal colon tissue.