Target：Tensin-2

Gene Name：TENC1

Protein Name：Tensin-like C1 domain-containing phosphatase

Human Gene Id：23371

Human Swiss Prot No：Q63HR2

Mouse Gene Id：209039

Mouse Swiss Prot No：Q8CGB6

Immunogen：Synthesized phospho-peptide around the phosphorylation site of human Tensin-2 (phospho Tyr483)

Specificity：Phospho-Tensin-2 (Y483) Polyclonal Antibody detects endogenous levels of Tensin-2 protein only when phosphorylated at Y483.

Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Source：Polyclonal, Rabbit,IgG

Dilution：WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration：1 mg/ml

Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)

Other Name：TENC1;KIAA1075;TNS2;Tensin-like C1 domain-containing phosphatase;C1 domain-containing phosphatase and tensin homolog;C1-TEN;Tensin-2

Observed Band(KD)：152kD

Background： The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008],

Function：function:Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling.,similarity:Contains 1 C2 tensin-type domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 phosphatase tensin-type domain.,similarity:Contains 1 SH2 domain.,subcellular location:Detected at the end of actin stress fibers.,subunit:Interacts with AXL.,tissue specificity:Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and small intestine.,

Subcellular Location：Cell junction, focal adhesion . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Detected at the end of actin stress fibers. Detected in cytoplasmic punctate bodies (PubMed:22019427). .

Expression：Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and small intestine.