Target：Tuberin
Fields：Phospholipase D signaling pathway;p53 signaling pathway;Autophagy - animal;mTOR signaling pathway;PI3K-Akt signaling pathway;AMPK signaling pathway;Longevity regulating pathway;Cellular senescence;Thermogenesis;Insulin signaling pathway;Thyroid hormone signaling pathway;Human cytomegalovirus infection;Human papillomavirus infection;Herpes simplex virus 1 infection;Choline metabolism in cancer
Gene Name：TSC2
Protein Name：Tuberin
Human Gene Id：7249
Human Swiss Prot No：P49815
Mouse Swiss Prot No：Q61037
Rat Gene Id：24855
Rat Swiss Prot No：P49816
Immunogen：The antiserum was produced against synthesized peptide derived from human TSC2 around the phosphorylation site of Tyr1571. AA range:1537-1586
Specificity：Phospho-Tuberin (Y1571) Polyclonal Antibody detects endogenous levels of Tuberin protein only when phosphorylated at Y1571.
Formulation：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source：Polyclonal, Rabbit,IgG
Dilution：WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
Purification：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration：1 mg/ml
Storage Stability：-15°C to -25°C/1 year(Do not lower than -25°C)
Other Name：TSC2;TSC4;Tuberin;Tuberous sclerosis 2 protein
Observed Band(KD)：170kD
Background： Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
Function：alternative products:Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms,disease:Defects in TSC2 are a cause of lymphangioleiomyomatosis (LAM) [MIM:606690]. LAM is a progressive and often fatal lung disease characterized by a diffuse proliferation of abnormal smooth muscle cells in the lungs. It affects almost exclusively young women and can occur as an isolated disorder or in association with tuberous sclerosis complex.,disease:Defects in TSC2 are the cause of tuberous sclerosis complex (TSC) [MIM:191100]. The molecular basis of TSC is a functional impairment of the tuberin-hamartin complex. TSC is an autosomal dominant multi-system disorder that affects especially the brain, kidneys, heart, and skin. TSC is characterized by hamartomas (benign overgrowths predominantly of a cell or tissue type that occurs normally in the organ) and hamartias (de
Subcellular Location：Cytoplasm. Membrane; Peripheral membrane protein. At steady state found in association with membranes.
Expression：Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta.
